Nuclear translocation of catalytic domain of Mst3 Mitochondrial recruitment of Drp1 Translocation of active caspase-8 to the mitochondrial membrane PathwayStep4408 PathwayStep4421 PathwayStep4426 PathwayStep4428 PathwayStep4427 PathwayStep4429 Apoptotic execution phase Authored: Alnemri, E, 2004-02-17 00:23:30 Edited: Matthews, L, 2008-02-12 16:13:52 GENE ONTOLOGYGO:0006921 In the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucleus and other organelles, DNA fragmentation, chromatin condensation, cell shrinkage and cell detachment and membrane blebbing (reviewed in Fischer et al., 2003). Pubmed12655297 Reactome Database ID Release 4375153 Reactome, http://www.reactome.org ReactomeREACT_995 Reviewed: Ranganathan, S, 2007-11-23 00:10:26 Apoptotic cleavage of cellular proteins Apoptosis induced DNA fragmentation Stimulation of the cell death response by PAK-2p34