Caspase-mediated cleavage of FADK 1 Caspase mediated cleavage of C-IAP1 Caspase mediated cleavage of APC Caspase-mediated cleavage of MST3 Caspase-mediated cleavage of MASK Caspase-mediated cleavage of claspin Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha Caspase-mediated cleavage of Rock-1 Caspase-mediated cleavage of Etk Caspase mediated cleavage of BAP31 Caspase 3-mediated cleavage of PKC delta Caspase-mediated cleavage of Acinus Caspase-mediated cleavage of PKC theta Cleavage of Satb1 PathwayStep4400 PathwayStep4403 PathwayStep4404 PathwayStep4401 PathwayStep4402 PathwayStep4407 PathwayStep4405 PathwayStep4406 PathwayStep4390 PathwayStep4395 PathwayStep4396 PathwayStep4393 PathwayStep4394 PathwayStep4399 PathwayStep4397 PathwayStep4398 PathwayStep4379 Apoptotic cleavage of cellular proteins Apoptotic cell death is achieved by the caspase-mediated cleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adducin, HIP-55, and desmoglein involved in cell adhesion and maintenance of the cytoskeletal architecture. Cleavage of proteins such as APC and CIAP1 can further stimulate apoptosis by produce proapoptotic proteins (reviewed in Fischer et al., 2003. See also Wee et al., 2006 and the CASVM Caspase Substrates Database: http://www.casbase.org/casvm/squery/index.html ). Authored: Schulze-Osthoff, K, 2007-09-03 07:52:18 Edited: Matthews, L, 2008-02-08 00:41:49 Pubmed12655297 Pubmed17254298 Pubmed17599937 Reactome Database ID Release 43111465 Reactome, http://www.reactome.org ReactomeREACT_107 Reviewed: Ranganathan, S, 2007-11-23 00:10:26 Caspase-mediated cleavage of cytoskeletal proteins Apoptotic cleavage of cell adhesion proteins Breakdown of the nuclear lamina