Caspase-mediated cleavage of E-Cadherin Caspase mediated cleavage of beta-catenin Caspase-mediated cleavage of Desmoglein 3 Caspase-mediated cleavage of Desmoglein 2 Caspase-mediated cleavage of Desmoglein 1 Caspase-mediated cleavage of occludin Caspase-mediated cleavage of Z0-2 Caspase-mediated cleavage of Z0-1 Caspase-mediated cleavage of plakophilin-1 Caspase-mediated cleavage of Desmoplakin PathwayStep4389 PathwayStep4388 PathwayStep4387 PathwayStep4386 PathwayStep4385 PathwayStep4384 PathwayStep4383 PathwayStep4382 PathwayStep4381 PathwayStep4380 Apoptotic cleavage of cell adhesion proteins Apoptotic cells show dramatic rearrangements of tight junctions, adherens junctions, and desmosomes (Abreu et al., 2000). Desmosome-specific members of the cadherin superfamily of cell adhesion molecules including desmoglein-3, plakophilin-1 and desmoplakin are cleaved by caspases after onset of apoptosis (Weiske et al., 2001). Cleavage results in the disruption of the desmosome structure and thus contributes to cell rounding and disintegration of the intermediate filament system (Weiske et al., 2001). Authored: Schulze-Osthoff, K, 2008-05-18 10:00:05 Edited: Matthews, L, 2008-06-12 00:23:53 Pubmed11500511 Pubmed16286477 Pubmed17559062 Reactome Database ID Release 43351906 Reactome, http://www.reactome.org ReactomeREACT_13579 Reviewed: Ranganathan, S, 2008-06-11 19:13:33