PathwayStep4445 PathwayStep4436 PathwayStep4433 Regulation of Apoptosis A regulated balance between cell survival and apoptosis is essential for normal development and homeostasis of multicellular organisms (see Matsuzawa, 2001). Defects in control of this balance may contribute to autoimmune disease, neurodegeneration and cancer. Protein ubiquitination and degradation is one of the major mechanisms that regulate apoptotic cell death (reviewed in Yang and Yu 2003). Authored: Jakobi, R, 2008-02-05 11:04:14 Edited: Matthews, L, 2008-02-12 16:13:24 Edited: Matthews, L, 2008-06-12 00:23:53 GENE ONTOLOGYGO:0042981 Pubmed11432772 Pubmed12724336 Reactome Database ID Release 43169911 Reactome, http://www.reactome.org ReactomeREACT_13648 Reviewed: Chang, E, 2008-05-21 00:05:41 Role of DCC in regulating apoptosis Regulation of activated PAK-2p34 by proteasome mediated degradation Regulation of PAK-2p34 activity by PS-GAP/RHG10