tBID binds to inactive BAX protein Oligomerization of BAX at the mitochondrial membrane Translocation of activated BAX to the mitochondria tBID activates BAX protein PathwayStep4339 PathwayStep4338 PathwayStep4337 PathwayStep4340 Activation, translocation and oligomerization of BAX As a result of binding to Bid, Bax oligomerizes and integrates in the outer mitochondrial membrane that triggers cytochrome c release. Bax mitochondrial membrane insertion triggered by Bid may represent a key step in pathways leading to apoptosis (Eskes et al., 2000). GENE ONTOLOGYGO:1901030 Pubmed10629050 Pubmed11136736 Pubmed12193163 Reactome Database ID Release 43114294 Reactome, http://www.reactome.org ReactomeREACT_584 subpathway of human intrinsic apoptosis pathway