Release of SMAC from mitochondria Release of Cytochrome c from mitochondria PathwayStep4347 PathwayStep4348 Release of apoptotic factors from the mitochondria Apoptotic factors released from the mitochondria promote apoptosis through several different mechanisms. Cytochrome C participates in Apoptosome driven effector caspase activation while SMAC relieves IAP mediated caspase inhibition. Authored: Matthews, L, 2004-08-06 15:00:00 Pubmed10913597 Pubmed12660240 Pubmed12941691 Pubmed15077149 Reactome Database ID Release 43111457 Reactome, http://www.reactome.org ReactomeREACT_1322 Reviewed: Vaux, D, 0000-00-00 00:00:00 subpathway of human intrinsic apoptosis pathway