PathwayStep4361 PathwayStep4365 SMAC-mediated dissociation of IAP:caspase complexes SMAC-mediated apoptotic response Authored: Matthews, L, 2004-08-06 15:00:00 Once released from the mitochondria, SMAC binds to IAP family proteins displacing them from Caspase:IAP complexes liberating the active caspases. Pubmed12042762 Pubmed15077149 Reactome Database ID Release 43111469 Reactome, http://www.reactome.org ReactomeREACT_666 Reviewed: Vaux, D, 0000-00-00 00:00:00 SMAC binds to IAPs