Cytochrome C Binds to Apaf-1 Cytochrome C:Apaf-1 binds Procaspase-9 Cleavage of Procaspase-9 to Caspase-9 PathwayStep4350 PathwayStep4352 PathwayStep4351 Formation of apoptosome Cytoplasmic cytochrome c binds to apoptotic protease activating factor-1 (Apaf-1) promoting the formation of an Apaf-1 oligomer (the apoptosome) which in turn binds and activates caspase-9. Pubmed10206961 Pubmed15184073 Reactome Database ID Release 43111458 Reactome, http://www.reactome.org ReactomeREACT_89