Translocation of tBID to mitochondria Granzyme-B activates BID by cleavage Myristoylation of tBID by NMT1 Caspase-8 activates BID by cleavage PathwayStep4307 PathwayStep4309 PathwayStep4308 PathwayStep4310 Activation of BID and translocation to mitochondria Activation, myristolyation of BID and translocation to mitochondria Authored: Gopinathrao, G, 2004-08-19 20:25:42 BID may promote cell death by activating BAX and BAK while inactivating anti-apoptotic proteins. The engagement of cell surface receptors activates the caspase-8, a heterodimer, that cleaves BID in its amino terminal region. This particular event may act as a link between Extrinsic (caspase 8/10 dependent) and Intrinsic (Bcl-2 inhibitable) pathways although some evidences from mouse genetic experiments suggest the contrary. It has been suggested that the death signals from the extrinsic or death receptor pathway may get amplified by the mechanisms of intrinsic pathway and that this functional loop may be enabled by the molecules like tBID (truncated BID).<BR> Cleavage of BID to tBID can also be achieved by Granzyme B. The truncated protein is myristoylated and translocates to mitochondria. GENE ONTOLOGYGO:1900740 Pubmed14634621 Pubmed9727492 Reactome Database ID Release 4375108 Reactome, http://www.reactome.org ReactomeREACT_701 Reviewed: Vaux, D, 0000-00-00 00:00:00