BAD displaces tBID from BCL-2 sequestration Translocation of activated BAD protein to mitochondria Activation of BAD by calcineurin Sequestration of BAD protein by 14-3-3 Akt1 phosphorylates BAD protein PathwayStep4316 PathwayStep4315 PathwayStep4314 PathwayStep4313 PathwayStep4312 Activation of BAD and translocation to mitochondria Authored: Gopinathrao, G, 2004-08-19 20:25:42 GENE ONTOLOGYGO:1900740 Pubmed12209154 Pubmed15231831 Reactome Database ID Release 43111447 Reactome, http://www.reactome.org ReactomeREACT_549 Reviewed: Vaux, D, 0000-00-00 00:00:00 The switching on/off of its phosphorylation by growth/survival factors regulates BAD activity. BAD remains sequestered by 14-3-3 scaffold proteins after phosphorylation by Akt1. Calcineurin activates BAD by dephosphorylation.