PathwayStep4300 PathwayStep4301 TRAIL Mediated Activation of Pro-caspase 8 TNF Mediated Activation of Pro-caspase 8 FAS Mediated Activation of Pro-caspase 8 PathwayStep4302 Activation of Pro-Caspase 8 GENE ONTOLOGYGO:0006919 Pro-caspase-8 is known to be activated by various factors in response to a variety of external and internal stimuli. These include FAS, TRAIL, and TNF. Reactome Database ID Release 4369416 Reactome, http://www.reactome.org ReactomeREACT_832