Translocation of PUMA protein to mitochondria PathwayStep4322 PathwayStep4323 PathwayStep4324 Transactivation of PUMA by E2F1 Transactivation of PUMA by p53 Activation of PUMA and translocation to mitochondria GENE ONTOLOGYGO:1900740 Pubmed11463392 Pubmed14684737 Puma is transactivated in a p53-dependent manner and by E2F1. Activated Puma is translocated to mitochondria. Reactome Database ID Release 43139915 Reactome, http://www.reactome.org ReactomeREACT_121