Translocation of BIM to mitochondria Phosphorylation of DLC1 by MAPK 8 PathwayStep4327 PathwayStep4326 Activation of BIM and translocation to mitochondria Authored: Gopinathrao, G, 2004-08-19 20:25:42 BIM acts as a sentinel to check the integrity of the cytoskeleton. It exists as two variant proteins: BIM-EL and BIM-L. In healthy cells, these two isoforms are sequestered to the dynein motor complex on microtubules via the dynein light chain DLC1. JNK or MAPK8 releases BIM in response to UV irradiation by phosphorylation. GENE ONTOLOGYGO:1900740 Pubmed14634621 Pubmed14764673 Reactome Database ID Release 43111446 Reactome, http://www.reactome.org ReactomeREACT_1650 Reviewed: Vaux, D, 0000-00-00 00:00:00