PathwayStep4297 PathwayStep4296 PathwayStep4295 PathwayStep4294 PathwayStep4293 TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-8 TRAIL:TRAIL receptor-2 Trimer Binds FADD TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-10 Trimerization of TRAIL: TRAIL receptor-2 complex TRAIL Binds TRAIL-Receptor2 TRAIL signaling Authored: Gillespie, ME, 2004-08-31 03:31:31 Edited: Gillespie, ME, 0000-00-00 00:00:00 Pubmed14634624 Reactome Database ID Release 4375158 Reactome, http://www.reactome.org ReactomeREACT_402 Tumor necrosis factor-related apoptosis-inducing ligand or Apo 2 ligand (TRAIL/Apo2L) is a member of the tumor necrosis factor (TNF) family. This group of apoptosis induction pathways all work through protein interactions mediated by the intracellular death domain (DD), encoded within the cytoplasmic domain of the receptor. TRAIL selectively induces apoptosis through its interaction with the Fas-associated death domain protein (FADD).