PathwayStep4284 PathwayStep4283 PathwayStep4285 PathwayStep4282 PathwayStep4281 FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10 FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 FasL:Fas binds FADD Trimerization of the FASL:FAS receptor complex FASL binds FAS Receptor FasL/ CD95L signaling Authored: Gillespie, ME, 2004-08-18 21:05:31 Edited: Gillespie, ME, 0000-00-00 00:00:00 GENE ONTOLOGYGO:0008624 Pubmed11048727 Pubmed1713127 Pubmed2469768 Pubmed7538907 Reactome Database ID Release 4375157 Reactome, http://www.reactome.org ReactomeREACT_900 Reviewed: Vaux, D, 0000-00-00 00:00:00 The Fas family of cell surface receptors initiate the apototic pathway through interaction with the external ligand, FasL. The cytoplasmic domain of Fas interacts with a number of molecules in the transduction of the external signal to the cytoplasmic side of the cell membrane. The most notable cytoplasmic domain is the Death Domain (DD) that is involved in recruiting the FAS-associating death domain-containing protein (FADD). This interaction drives downstream events.