PathwayStep4291 PathwayStep4290 PathwayStep4288 PathwayStep4287 PathwayStep4289 TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. TRADD:TRAF2:RIP1 complex binds FADD TNF Binds TNF-R1 TNF:TNF-R1 binds TRADD, TRAF2 and RIP Complex TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 TNF signaling Authored: Gillespie, ME, 2004-08-24 21:32:45 Edited: Gillespie, ME, 0000-00-00 00:00:00 Pubmed12040173 Reactome Database ID Release 4375893 Reactome, http://www.reactome.org ReactomeREACT_1432 The Tumor Necrosis Factor alpha (TNF-alpha) mediated apoptosis pathway has been implicated in the pathogenesis of a number of diseases including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases. The TNF signaling network provides extensive cross talk between the apoptotic pathway, and the other NF-B, and JNK pathways that also emanate from TNF-R.