PathwayStep4299 PathwayStep4305 Caspase-8 is formed from procaspase-8 Extrinsic Pathway for Apoptosis Authored: Gillespie, ME, 2004-08-10 16:59:18 Edited: Gillespie, ME, 0000-00-00 00:00:00 GENE ONTOLOGYGO:0008624 Known as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, tumor necrosis factor-alpha (TNF-alpha) receptor 1, and two receptors, DR4 and DR5, that bind to the TNF-alpha related apoptosis-inducing ligand (TRAIL). The extrinsic and intrinsic pathways unite in the activation of Caspase-3, though the two pathways communicate through the pro-apoptotic Bcl-2 family member Bid before uniting at the shared activation of Caspase-3. Pubmed11048727 Reactome Database ID Release 43109607 Reactome, http://www.reactome.org ReactomeREACT_1059 Reviewed: Vaux, D, 0000-00-00 00:00:00 Death Receptor Signalling