PathwayStep4298 PathwayStep4292 PathwayStep4286 TRAIL signaling FasL/ CD95L signaling TNF signaling Death Receptor Signalling Authored: Gillespie, ME, 2004-08-10 16:59:18 Edited: Gillespie, ME, 0000-00-00 00:00:00 GENE ONTOLOGYGO:0008624 Reactome Database ID Release 4373887 Reactome, http://www.reactome.org ReactomeREACT_1619 Reviewed: Vaux, D, 0000-00-00 00:00:00 The death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif found on all of the three receptors (FAS/CD95, TNF-receptor, and TRAIL-receptor) that binds the Fas-associated protein with death domain (FADD)