PathwayStep4256 PIP3 activates AKT signaling Constitutive PI3K/AKT Signaling in Cancer PI3K/AKT Signaling in Cancer Authored: Orlic-Milacic, M, 2012-07-18 Edited: Matthews, L, 2012-08-03 Pubmed17604717 Pubmed19644473 Pubmed21430697 Reactome Database ID Release 432219528 Reactome, http://www.reactome.org ReactomeREACT_147723 Reviewed: Thorpe, Lauren, 2012-08-13 Reviewed: Yuzugullu, Haluk, 2012-08-13 Reviewed: Zhao, Jean J, 2012-08-13 This pathway describes how normal signaling by PI3K/AKT, presented in the contained module 'PIP3 Activates AKT Signaling' and recently reviewed by Manning and Cantley in 2007, is perturbed in cancer, as described in the contained module 'Constitutive Signaling by PI3K/AKT'. Please refer to Liu et al. 2009 and Hollander et al. 2011 for recent reviews. PathwayStep3897