PathwayStep4133 PathwayStep4130 PathwayStep4131 PathwayStep4132 PathwayStep4129 PathwayStep4128 GRB2:GAB1:PI3Kreg binds to p-SHP2 on p-FRS2:activated FGFR PI3K catalytic subunit is recruited by FGFR-associated PI3KR1 GRB2:GAB1:PI3Kreg binds directly to p-FRS2:activated FGFR FGFR-associated PI3K phosphorylates PIP2 to PIP3 FGFR associated PI3K phosphorylates PIP2 to PIP3 PI3K catalytic subunit binds to GRB2:GAB1:PI3Kreg (indirect) Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 PIP3 activates AKT signaling PI-3K cascade Authored: de Bono, B, 2007-01-10 10:27:18 Edited: Jupe, S, 2010-02-03 Pubmed10918587 Pubmed11057895 Pubmed12089343 Pubmed12558974 Pubmed15863030 Reactome Database ID Release 43190926 Reactome, http://www.reactome.org ReactomeREACT_21270 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 The ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which in turn affects the activity or expression of pro-apoptotic factors, which contribute to protection from apoptosis. AKT activation also blocks the activity of GSK-3b which could lead to additional antiapoptotic signals. PathwayStep3897 PathwayStep3865