PathwayStep2543 PathwayStep2542 PathwayStep2545 PathwayStep2544 PathwayStep2547 PathwayStep2546 Catecholamine biosynthesis Authored: Jassal, B, 2008-10-01 13:18:42 Edited: Jassal, B, 2008-05-28 09:06:10 GENE ONTOLOGYGO:0042423 Pubmed10691773 Pubmed1684650 Pubmed363400 Reactome Database ID Release 43209905 Reactome, http://www.reactome.org ReactomeREACT_15551 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54 The catecholamine neurotransmitters dopamine, noradrenaline and adrenaline are found in nervous tissue of animals. They are synthesized in catecholaminergic neurons by four enzymes from tyrosine to adrenaline: tyrosine hydroxylase (TH); aromatic L-amino acid decarboxylase (AADC); dopamine beta-hydroxylase (DBH); and phenylethanolamine N-methyltransferase (PNMT). Tyrosine is hydroxylated to dopa Dopamine is oxidised to noradrenaline Dopamine translocates to a secretory vesicle Dopa is decarboxylated to dopamine Noradrenaline translocates to the cytosol Noradrenaline is converted to adrenaline