PathwayStep2580 PathwayStep2579 PathwayStep2577 PathwayStep2578 PathwayStep2575 PathwayStep2576 PathwayStep2574 Glyoxylate metabolism Authored: D'Eustachio, P, 2009-01-11 19:48:01 Edited: D'Eustachio, P, 2009-03-03 14:28:53 GENE ONTOLOGYGO:0046487 Glyoxylate is generated in the course of glycine and hydroxyproline catabolism and can be converted to oxalate. In humans, this process takes place in the liver. Defects in two enzymes of glyoxylate metabolism, alanine:glyoxylate aminotransferase (AGXT) and glycerate dehydrogenase/glyoxylate reductase (GRHPR), are associated with pathogenic overproduction of oxalate (Danpure 2005). The reactions that interconvert glycine, glycolate, and glyoxylate and convert glyoxylate to oxalate have been characterized in molecular detail in humans. A reaction sequence for the conversion of hydroxyproline to glyoxylate has been inferred from studies of partially purified extracts of rat and bovine liver but the enzymes involved in the corresponding human reactions have not been identified. Pubmed15956068 Reactome Database ID Release 43389661 Reactome, http://www.reactome.org ReactomeREACT_16925 Reviewed: Jassal, B, 2009-03-03 14:29:24 Synthesis of glyoxylate from hydroxyproline Conversion of glyoxylate to oxalate glycolate + O2 => glyoxylate + H2O2 glyoxylate + alanine => glycine + pyruvate [peroxisome] glycine + O2 => glyoxylate + H2O2 + NH4+ glyoxylate + NADPH + H+ => glycolate + NADP+ glyoxylate + alanine => glycine + pyruvate [mitochondrial matrix]