PathwayStep2641 PathwayStep2642 PathwayStep2643 PathwayStep2651 PathwayStep2650 PathwayStep2656 PathwayStep2654 PathwayStep2655 PathwayStep2652 PathwayStep2653 PathwayStep2640 PathwayStep2639 PathwayStep2638 PathwayStep2633 PathwayStep2637 PathwayStep2636 Xenobiotics Authored: Jassal, B, 2008-05-19 12:57:01 Edited: Jassal, B, 2008-05-19 12:57:01 Of the 50 microsomal CYPs, 15 act on xenobiotics. They all possess wide substrate specificity to cater for most foreign compounds that find their way into the body. Pubmed12369887 Pubmed15102545 Pubmed16584116 Reactome Database ID Release 43211981 Reactome, http://www.reactome.org ReactomeREACT_13543 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54 CYP2E1 reactions Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide CYP2F1 dehydrogenates 3-methylindole CYP3A4 can N-demethylate loperaminde O-atom dealkylation of dextromethorphan CYP2D6 4-hydroxylates debrisoquine CYP2C19 5-hydroxylates omeprazole Cyclophosphamide is 4-hydroxylated by CYP2B6 CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation Coumarin is 7-hydroxylated by CYP2A13 Coumarin is 7-hydroxylated by CYP2A6 Ethylene oxidized to Ethylene oxide CYP3A7 can 6beta-hydroxylate testosterone