PathwayStep1559 PathwayStep1588 PathwayStep1516 4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one 4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one 4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one Sterols are 12-hydroxylated by CYP8B1 Authored: Jassal, B, 2008-05-19 12:57:01 Cytochrome P450 8B1 (CYP8B1, sterol 12-alpha- hydroxylase) has a broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids. It is also involved in bile acid synthesis and is responsible for the balance between the formation of cholic acid and chenodeoxycholic acid. Edited: Jassal, B, 2008-05-19 12:57:01 Pubmed10051404 Reactome Database ID Release 43211994 Reactome, http://www.reactome.org ReactomeREACT_13438 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54