PathwayStep1909 PathwayStep1907 PathwayStep1919 LTB4 is hydroxylated to 20oh-LTB4 by CYP4F2/4F3 PGH2 is isomerised to TXA2 by TBXAS1 PGH2 is isomerised to PGI2 by PTGIS PathwayStep2663 Eicosanoids Arachidonic acid is metabolized via three major enzymatic pathways: cyclooxygenase, lipoxygenase, and cytochrome P450. The cytochrome P450 pathway metabolites are oxygenated metabolites of arachidonic acid. Authored: Jassal, B, 2008-05-19 12:57:01 Edited: Jassal, B, 2008-05-19 12:57:01 GENE ONTOLOGYGO:0006690 Pubmed15102545 Pubmed16584116 Pubmed7922394 Reactome Database ID Release 43211979 Reactome, http://www.reactome.org ReactomeREACT_13645 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54 CYP4F8 hydroxylates prostaglandin H2