PathwayStep2645 PathwayStep2646 PathwayStep2647 PathwayStep2648 PathwayStep2644 PathwayStep2649 CYP2E1 reactions Authored: Jassal, B, 2008-05-19 12:57:01 CYP2E1 can metabolize and activate a large number of solvents and industrial monomers as well as drugs. This quality of CYP2E1 may make it an important determinant of human susceptibility to the toxic effects of industrial and environmental chemicals. Typical CYP2E1 substrates include acetaminophen, benzene, CCl4, halothane, ethanol and vinyl chloride. CYP2E1 contributes to oxidative stress by producing oxidising species called reactive oxygen species (ROS) which can lead to damage to mitochondria, DNA and initiate lipid peroxidation or even cell death. Edited: Jassal, B, 2008-05-19 12:57:01 Pubmed10397283 Pubmed14744237 Pubmed15603755 Reactome Database ID Release 43211999 Reactome, http://www.reactome.org ReactomeREACT_13797 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54 Vinyl chloride is oxidized to 2-Chloroethylene oxide MEOS oxidizes ethanol to acetaldehyde Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide Dehalogenation of carbon tetrachloride to form a free radical Benzene is hydroxylated to phenol Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)