PathwayStep2746 PathwayStep2745 Conjugation of benzoate with glycine Authored: Jassal, B, 2004-11-30 16:21:24 Benzoic acid, widely used as a food preservative, is converted to hippuric acid by activation and conjugation with glycine. This was one of the first detoxification pathways discovered, and was formerly exploited clinically as an alternative means of nitrogen excretion in patients with urea cycle defects (Brusilow and Horwich 2001). Edited: D'Eustachio, P, 2006-03-23 15:51:01 GENE ONTOLOGYGO:0006805 ISBN0079130356 Reactome Database ID Release 43177135 Reactome, http://www.reactome.org ReactomeREACT_6933 Benzoate and Coenzyme A react to form benzoyl-CoA thioester Benzoyl-CoA forms an amide bond with glycine