PathwayStep2752 PathwayStep2751 Conjugation of salicylate with glycine Authored: Jassal, B, 2004-11-30 16:21:24 Edited: D'Eustachio, P, 2006-03-23 15:51:01 GENE ONTOLOGYGO:0006805 In the body, aspirin (acetylsalicylic acid) is hydrolyzed to salicylic acid. Salicylic acid (2-hydroxybenzoic acid) can then be hydroxylated to yield gentisic acid, conjugated with glucuronate, or conjugated with glycine to yield molecules that are excreted by the kidneys. The third of these conjugation processes is annotated here, and proceeds in two steps. First, salicylate and ATP react with coenzyme A to form salicylate CoA, AMP, and pyrophosphate in a reaction catalyzed by xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Second, salicylate CoA and glycine react to form salicyluric acid and Coenzyme A (Mawal and Qureshi 1994). Pubmed12616642 Pubmed7802672 Reactome Database ID Release 43177128 Reactome, http://www.reactome.org ReactomeREACT_6812 Salicylate-CoA forms an amide bond with glycine Salicylic acid and Coenzyme A react to form salicylate-CoA thioester