PathwayStep2734 PathwayStep2736 PathwayStep2735 PathwayStep2738 PathwayStep2737 PathwayStep2739 PathwayStep2740 PathwayStep2590 PathwayStep2589 Glutathione synthesis and recycling Authored: Jassal, B, 2004-11-30 16:21:24 Edited: Jassal, B, 2008-05-19 12:57:01 GENE ONTOLOGYGO:0006750 Pubmed3053703 Reactome Database ID Release 43174403 Reactome, http://www.reactome.org ReactomeREACT_6960 Reviewed: D'Eustachio, P, 2011-05-23 The combination of glutamate, cysteine and ATP is required to form glutathione. The steps involved in the synthesis and recycling of glutathione are outlined (Meister, 1988). A dipeptidase cleaves cysteinylglycine Glutamate and cysteine combine Cleavage of 5-oxoproline to form glutamate Cysteinylglycine and gamma-glutamate:AA are imported into the cell 5-oxoproline can be formed from gamma-glutamyl-AA products Formation of 5-oxoproline from gamma-glutamylcysteine gamma-glutamylcysteine combines with glycine to form glutathione Export of glutathione to the extracellular space Glutathione is hydrolyzed