PathwayStep2784 PathwayStep2785 PathwayStep2786 PathwayStep2787 PathwayStep2788 PathwayStep2789 PathwayStep2790 Abacavir metabolism Abacavir activation proceeds steps of phosphorylation, deamination to yield carbovir monophosphate, and phosphorylation of the latter compound to yield the triphosphate. In addition, abacavir can be conjugated with glucuronide or oxidized to its 5'-carboxylate derivative, the two major forms in which it is excreted from the body (Yuen et al. 2008). Authored: D'Eustachio, P, 2012-03-14 Edited: D'Eustachio, P, 2012-03-16 GENE ONTOLOGYGO:0017144 Pubmed18479171 Reactome Database ID Release 432161541 Reactome, http://www.reactome.org ReactomeREACT_121388 Reviewed: Jassal, B, 2012-03-16 Oxidation of abacavir to abacavir 5'-carboxylate Glucuronidation of abacavir Deamination of abacavir monophosphate to form carbovir monophosphate Phosphorylation of abacavir Phosphorylation of carbovir monophosphate Conversion of carbovir to carbovir monophosphate Phosphorylation of carbovir diphosphate