PathwayStep2824 PathwayStep2827 PathwayStep2828 PathwayStep2825 PathwayStep2826 PathwayStep2829 Recognition and association of DNA glycosylase with site containing an affected purine Authored: Matthews, L, 2004-02-09 03:00:00 GENE ONTOLOGYGO:0045007 Pubmed9724657 Reactome Database ID Release 43110330 Reactome, http://www.reactome.org ReactomeREACT_2176 The recognition and cleavage of an altered base by a DNA glycosylase is thought to involve the diffusion of the enzyme along the minor grove of the DNA molecule. The enzyme presumably compresses the backbone of the affected DNA strand at the site of damage. This compression is thought to result in an outward rotation of the damaged residue into a "pocket" of the enzyme that recognizes and cleaves the altered base (Parikh et al., 1998). hOGG1 glycosylase mediated recognition and binding of an 8-oxo guanine opposite to a cytosine hOGG1 glycosylase mediated recognition and binding of a formamidopyrimidine MYH glycosylase mediated recognition and binding of an adenine opposite to an 8-oxo guanine MPG glycosylase mediated recognition and binding of hypoxanthine MPG glycosylase mediated recognition and binding of ethenoadenine MPG glycosylase mediated recognition and binding of 3-methyladenine