PathwayStep2818 PathwayStep2819 PathwayStep2816 PathwayStep2817 NICD traffics to nucleus Authored: Jassal, B, 2005-01-10 12:51:46 NICD translocates to the nucleus and assembles into a ternary complex with the CSL (human RBPJ i.e. CBF1/ fly Suppressor of Hairless/ worm Lag1) DNA-binding protein and the Mastermind co-activator. This complex activates the transcription of downstream gene targets like HES (Hairy/Enhancer of Split) and HES-related (HRT, also named CHF, HEY, HESR, gridlock) genes. Reactome Database ID Release 43157052 Reactome, http://www.reactome.org ReactomeREACT_2155 Formation of CSL-NICD coactivator complex PathwayStep97 NICD4 traffics to the nucleus NICD1 traffics to the nucleus NICD3 traffics to the nucleus NICD2 traffics to the nucleus