PathwayStep411 3' -UTR-mediated translational regulation Authored: Matthews, L, 2004-12-20 12:26:45 Edited: Matthews, L, 0000-00-00 00:00:00 Pubmed11533233 Pubmed12575997 Pubmed15459663 Reactome Database ID Release 43157279 Reactome, http://www.reactome.org ReactomeREACT_1762 Translational control mechanisms often involve interactions between the 3' - or 5' -untranslated regions (UTRs) of mRNA and RNA-binding proteins. One such mechanism requires circularization of the mRNA molecule involving protein-protein interactions between the mRNA termini (Mazumder et al., 2001). While the circularization of mRNA during translation initiation is thought to contribute to an increase in the efficiency of translation, it also appears to provide a mechanism for translational silencing. This might be achieved by bringing inhibitory 3' UTR-binding proteins into a position in which they interfere either with the function of the translation initiation complex or with the assembly of the ribosome. L13a-mediated translational silencing of Ceruloplasmin expression