PathwayStep2891 PathwayStep2890 PathwayStep2887 PathwayStep2888 PathwayStep2889 PathwayStep2885 PathwayStep2886 PathwayStep2875 PathwayStep2877 PathwayStep2876 Removal of DNA patch containing abasic residue During removal of DNA patch containing abasic residue, DNA glycosylase is displaced by APE1 which endonucleolytically cleaves the 5' side of the base-free deoxyribose residue. POL Beta is recruited to the AP site where it mediates incorporation of the first replacement nucleotide. Association of POL delta with the AP site displaces POL Beta. DNA strand displacement synthesis then follows and flap structures are cleaved. Reactome Database ID Release 43110362 Reactome, http://www.reactome.org ReactomeREACT_2192 Displacement of DNA glycosylase by APE1 APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue Recruitment of POL Beta to the AP site Interaction of APE1 with DNA ligase I Interaction of APE1 with FEN1 POL delta associates with AP site displacing POL Beta DNA strand displacement synthesis POL Beta mediated incorporation of the first replacement nucleotide Interaction between FEN1 and PCNA Cleavage of flap structures