PathwayStep2875 PathwayStep2877 PathwayStep2876 PathwayStep2878 Displacement of DNA glycosylase by APE1 Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway requires displacement of DNA glycosylase by APE1, APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, recruitment of POL Beta to the AP site and Excision of the abasic sugar phosphate (dRP) residue at the strand break (Lindahl and Wood, 1999). Pubmed10583946 Reactome Database ID Release 4373930 Reactome, http://www.reactome.org ReactomeREACT_1357 APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue Recruitment of POL Beta to the AP site Excision of the abasic sugar phosphate (dRP) residue at the strand break