PathwayStep2901 PathwayStep2903 PathwayStep2902 Translesion synthesis by Pol eta Authored: Gopinathrao, G, 2004-02-02 17:30:34 Pol eta consists of 713 amino acids and can bypass thymidine-thymidine dimers adding two A’s correctly opposite to the lesion. Mutations in Pol eta gene result in the loss of this bypass activity in accounting for the XP variant phenotype (XPV) among human xeroderma pigmentosum disorder patients. Pol eta can carry out TLS past various UV and chemical induced lesions via two steps: a. preferential incorporation of correct bases opposite to the lesion<BR>b. conditional elongation only at the sites where such correct bases are inserted.<BR> Pubmed10369688 Pubmed10856253 Reactome Database ID Release 43110320 Reactome, http://www.reactome.org ReactomeREACT_1287 Insertion of correct bases opposite to the lesion by Pol eta Elongation by Pol eta Binding of Pol eta to lesioned DNA template