PathwayStep2962 PathwayStep2929 PathwayStep2940 PathwayStep2943 PathwayStep2954 PathwayStep2955 Homologous recombination repair of replication-independent double-strand breaks Homologous recombination repair of replication-independent double-strand breaks requires the activation of ATM followed by ATM mediated phosphorylation of DNA repair proteins. DNA repair and signaling proteins are then recruited to double-strand breaks. The ends of the DNA double strand breaks must be resectioned and RPA complexes associate with the resulting ssDNA. Homologous DNA pairing and strand exchange then occurs followed by DNA repair synthesis and resolution of D-loop structures. Reactome Database ID Release 4373951 Reactome, http://www.reactome.org ReactomeREACT_1587 Processing of DNA double-strand break ends Recruitment of repair and signaling proteins to double-strand breaks ATM mediated response to DNA double-strand break Resolution of D-loop structures Homologous DNA pairing and strand exchange DNA repair synthesis