PathwayStep2937 PathwayStep2933 Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks MRN complex relocalizes to nuclear foci Authored: Matthews, L, 2003-11-23 12:20:00 MRN complexes localize to nuclear foci in response to double-strand breaks and have been implicated in DNA end-processing during homologous recombination repair (Trujillo et al., 1998). The MRN complex may function as a bridge between double-strand break ends through interactions between the coiled-coil domains of RAD50 (Hoptner et al., 2002). Pubmed12152085 Pubmed9554850 Pubmed9705271 Reactome Database ID Release 4383572 Reactome, http://www.reactome.org ReactomeREACT_1884 Association of gamma-H2AX with NBS1