PathwayStep2928 PathwayStep2922 PathwayStep2923 ATM mediated response to DNA double-strand break Authored: Matthews, L, 2003-11-18 00:00:00 Detection of DNA double-strand breaks involves sensor proteins that become activated setting off of signaling cascades. This signaling leads to the recruitment of repair proteins and subsequent repair of the damaged DNA. ATM is one of the primary candidate sensors in double-strand break repair. Pubmed12034743 Reactome Database ID Release 4383542 Reactome, http://www.reactome.org ReactomeREACT_204 ATM mediated phosphorylation of repair proteins Intermolecular autophosphorylation of ATM within dimeric ATM complexes Dissociation of dimeric phospho-ATM complexes