PathwayStep104 PathwayStep105 PathwayStep106 PathwayStep107 PathwayStep102 PathwayStep103 Expression of NPPA (ANF) Expression of CTGF YAP1- and WWTR1 (TAZ)-stimulated gene expression Authored: D'Eustachio, P, 2012-02-03 Edited: D'Eustachio, P, 2012-01-06 GENE ONTOLOGYGO:0006367 Pubmed16332960 Pubmed20452772 Reactome Database ID Release 432032785 Reactome, http://www.reactome.org ReactomeREACT_118713 Reviewed: Sudol, M, 2012-02-03 YAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 interacts as well with TBX5 and RUNX2, to promote gene expression. Their transcriptional targets include genes critical to regulation of cell proliferation and apoptosis. Their subcellular location is regulated by the Hippo signaling cascade: phosphorylation mediated by this cascade leads to the cytosolic sequestration of both proteins (Murakami et al. 2005; Oh and Irvine 2010). WWTR1 (TAZ), TBX5, and PCAF form a complex WWTR1 (TAZ) binds RUNX2 WWTR1 (TAZ) binds TEAD YAP1 binds TEAD