PathwayStep125 PathwayStep147 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Authored: Orlic-Milacic, M, 2012-04-04 Edited: Jassal, B, 2012-04-10 GENE ONTOLOGYGO:0006351 In the nucleus, SMAD2/3:SMAD4 heterotrimer complex acts as a transcriptional regulator. The activity of SMAD2/3 complex is regulated both positively and negatively by association with other transcription factors (Chen et al. 2002, Varelas et al. 2008, Stroschein et al. 1999, Wotton et al. 1999) . In addition, the activity of SMAD2/3:SMAD4 complex can be inhibited by nuclear protein phosphatases and ubiquitin ligases (Lin et al. 2006, Dupont et al. 2009). Pubmed10199400 Pubmed10531062 Pubmed12150994 Pubmed16751101 Pubmed18568018 Pubmed19135894 Reactome Database ID Release 432173793 Reactome, http://www.reactome.org ReactomeREACT_121061 Reviewed: Huang, Tao, 2012-05-14 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity