PathwayStep211 PathwayStep149 PathwayStep330 PathwayStep321 PathwayStep309 PathwayStep380 PathwayStep348 PathwayStep264 PathwayStep434 PathwayStep442 Non-coding RNA Metabolism RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Generic Transcription Pathway Processing of Capped Intronless Pre-mRNA Gene Expression Authored: Kornblihtt, AR, Proudfoot, NJ, Caudy, M, D'Eustachio, P, 2008-12-03 01:43:15 Edited: Joshi-Tope, G, 0000-00-00 00:00:00 GENE ONTOLOGYGO:0010467 Gene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are processed. Most annotation is centered on the generation of messenger RNAs (mRNAs) by regulated RNA polymerase II (PolII) transcription, although the activities of PolI and PolIII are also covered briefly, as are some aspects of microRNA generation and function.<p>Aspects of mRNA synthesis annotated here include the assembly of transcription factor complexes and their role in targeting specific genes for transcription, PolII-mediated transcription (RNA synthesis) itself, and the co- and post-translational processing of this RNA, via capping, splicing, and 3'-cleavage and polyadenylation to yield mature mRNA molecules that are exported from the nucleus. mRNA editing and nonsense-mediated decay are also annotated. Processes leading to mRNA breakdown are described: deadenylation-dependent mRNA decay, microRNA-mediated RNA cleavage, and regulation of mRNA stability by proteins that bind AU-rich elements.<p>Other pathways included here are tRNA aminoacylation and snRNP assembly. Reactome Database ID Release 4374160 Reactome, http://www.reactome.org ReactomeREACT_71 RNA Polymerase II Transcription Regulatory RNA pathways Nonsense-Mediated Decay tRNA Aminoacylation Deadenylation-dependent mRNA decay Translation Regulation of mRNA Stability by Proteins that Bind AU-rich Elements Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Editing PathwayStep12 PathwayStep85 PathwayStep71 PathwayStep29