PathwayStep217 PathwayStep216 PathwayStep215 PathwayStep214 PathwayStep219 PathwayStep218 PathwayStep213 PathwayStep212 PathwayStep221 PathwayStep222 PathwayStep223 PathwayStep224 PathwayStep220 PathwayStep225 PathwayStep226 PathwayStep227 PathwayStep228 Abortive initiation after formation of the first phosphodiester bond Formation of P-TEFb complex Formation of NELF complex Formation of FACT complex Formation of Elongin BC complex Formation of DSIF complex Abortive Initiation Before Second Transition Abortive Initiation After Second Transition 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing Resumption of elongation after recovery from pausing Formation of elongin complex Fall Back to Closed Pre-initiation Complex Elongating transcript encounters a lesion in the template TFIIS-mediated recovery of elongation from arrest 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest Abortive termination of elongation after arrest Abortive termination of early transcription elongation by DSIF:NELF RNA Polymerase II Pre-transcription Events Reactome Database ID Release 43674695 Reactome, http://www.reactome.org ReactomeREACT_22107