PathwayStep175 PathwayStep186 PathwayStep187 PathwayStep185 PathwayStep188 RNA Polymerase III Promoter Opening at Type 1 Promoters Binding of TFIIIA To type 1 Promoter Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex Binding of TFIIIC to TFIIIA:Type I Promoter complex RNA Polymerase III Transcription Initiation From Type 1 Promoter Authored: Hernandez, N, 2003-09-11 07:42:29 Edited: Joshi-Tope, G, 0000-00-00 00:00:00 Pubmed3967290 Pubmed3972795 Pubmed6153931 Pubmed6356356 Pubmed7226225 Reactome Database ID Release 4376061 Reactome, http://www.reactome.org ReactomeREACT_347 The type 1 promoters recruit TFIIIA, the founding member of the C2H2 zinc finger family of DNA-binding proteins (Engelke et al., 1980; Sakonju et al., 1981). The binding of TFIIIA then allows the binding of TFIIC (Lassar et al., 1983), a complex consisting of five subunits (which differs from the six subunits in S. cerevisiae) in human cells and S. pombe. Once the DNA/TFIIIA/TFIIIC complex is formed, Brf1-TFIIIB joins the complex and this in turn allows the recruitment of RNA polymerase III (Bieker et al., 1985; Setzer and Brown, 1985).