PathwayStep168 PathwayStep167 PathwayStep166 PathwayStep165 Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box TTF-I binds to the Sal Box Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box RNA Polymerase I Transcription Termination Authored: Comai, L, 2003-07-03 17:28:24 Edited: Gillespie, ME, 0000-00-00 00:00:00 GENE ONTOLOGYGO:0006363 Reactome Database ID Release 4373863 Reactome, http://www.reactome.org ReactomeREACT_1074 Termination of transcription by RNA polymerase I is a 4 step process. Initially TTF-1 binds the template rDNA. This complex pauses polymerase I allowing PTRF to interact with the quaternary complex releasing both pre-rRNA and Pol I from the template and TTF-1.