PathwayStep301 PathwayStep300 PathwayStep307 PathwayStep306 PathwayStep303 PathwayStep302 PathwayStep305 PathwayStep304 PathwayStep289 PathwayStep288 PathwayStep287 PathwayStep292 PathwayStep293 PathwayStep290 PathwayStep291 PathwayStep299 PathwayStep298 PathwayStep295 PathwayStep294 PathwayStep297 PathwayStep296 pyrophosphate + H2O => 2 orthophosphate [mitochondrial] valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate Mitochondrial tRNA aminoacylation Authored: D'Eustachio, P, 2008-11-29 15:41:00 Edited: D'Eustachio, P, 2008-11-29 15:41:00 GENE ONTOLOGYGO:0006418 Mitochondrial tRNA synthetases act in the mitochondrial matrix to catalyze the reactions of tRNAs encoded in the mitochondrial genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate (Schneider et al. 2000). The synthetase enzymes that catalyze these reactions are all encoded in the nuclear genome. In three cases, glycine, lysine, and glutamine, a single gene encodes two enzyme isoforms, one cytosolic and one mitochondrial. All other mitochondrial tRNA synthetases are encoded by genes different from the ones encoding the corresponding cytosolic enzymes. Pubmed11121736 Reactome Database ID Release 43379726 Reactome, http://www.reactome.org ReactomeREACT_15302 Reviewed: Antonellis, A, 2008-12-02 16:58:45