PathwayStep2979 PathwayStep2984 PathwayStep2987 PathwayStep2992 Global Genomic NER (GG-NER) Authored: Gopinathrao, G, 2004-02-02 17:30:34 GG-NER is considered to be transcription-independent, removing lesions from non-transcribed regions of genome in addition to non-transcribed strands of transcribed regions.<BR> The three events that characterize NER are well characterized in GG-NER: damage recognition, bimodal incision of DNA via repair protein complex, resulting excision of DNA fragment with the lesion. Post-excision polymerization and ligation restore back the native chemistry and configuration to the damaged DNA.<BR> Reactome Database ID Release 43109970 Reactome, http://www.reactome.org ReactomeREACT_2253 DNA Damage Recognition in GG-NER Formation of incision complex in GG-NER Dual incision reaction in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER