PathwayStep2978 PathwayStep2977 DNA Damage Recognition in GG-NER Authored: Joshi-Tope, G, 2003-07-14 15:01:00 GENE ONTOLOGYGO:0000715 Reactome Database ID Release 4373940 Reactome, http://www.reactome.org ReactomeREACT_476 Several subunits of the NER multiprotein repair machinery are required for the recognition of damage in DNA. Mainly, XPC, HR23B, XPA and RPA are implicated in this process. XPA and RPA are thought to be binding to the damage site after the binding of XPC-HR23B complex.<BR> XPC:HR23B complex binds to damaged DNA site with lesion XPC binds to HR23B forming a heterodimeric complex