PathwayStep393 PathwayStep392 Formation of translation initiation complexes containing mRNA that does not circularize Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation Translation initiation complex formation Pubmed592399 Pubmed641056 Pubmed6853548 Pubmed9732867 Reactome Database ID Release 4372649 Reactome, http://www.reactome.org ReactomeREACT_1979 The translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. eIF1A is necessary for the formation of this complex.