PathwayStep384 PathwayStep385 PathwayStep386 Formation of the 43S pre-initiation complex De novo formation of eIF2:GTP Met-tRNAi binds to eIF2:GTP to form the ternary complex Formation of the ternary complex, and subsequently, the 43S complex Binding of the methionyl-tRNA initiator to the active eIF2:GTP complex results in the formation of the ternary complex. Subsequently, this Met-tRNAi:eIF2:GTP (ternary) complex binds to the complex formed by the 40S subunit, eIF3 and eIF1A, to form the 43S complex. Pubmed1104615 Pubmed429297 Pubmed592399 Pubmed641056 Reactome Database ID Release 4372695 Reactome, http://www.reactome.org ReactomeREACT_1079